Drugs to treat insomnia
There are many drugs on the market to solve sleeping disorders like insomnia. Zopiclone is so far the best drug with an excellent marketing profile. Zopiclone 7.5mg is an effective drug that treats long-term as well as short-term insomnia. Insomnia treatment has become a possibility due to the availability of sleeping drugs. Though there are many drugs to choose from, one should buy zopiclone 7.5mg to overcome issues faced by insomnia.
Benzodiazepine- Hypnotics for insomnia treatment
Benzodiazepines act as antagonists and bind to GABA receptors and GABA. The overdosing risk and abuse potential are very less as compared to the barbiturates. Benzodiazepines act by increasing the sleep time of an individual. They act by improving sleep quality by reducing sleep-onset latency and reducing the wakefulness after sleep onset by increasing the efficiency of sleep.
The central nervous system is depressed with sedatives and alcohol. Benzodiazepines have been approved by FDA for treating insomnia. These include: Retoril, Doral, Flurazepam, Estazolam, Dalmane and temazepam. They are categorized as rapidly acting drugs as they have a shorter half-life. Temazepam has a slower onset of action due to its relatively reduced effectiveness. Quazepam and Flurazepam on the other hand have longer half-lives more than 24 hours.
For short-term treatment- benzodiazepines are most useful. Increased dependence can result in addiction which is a habit that is hard to get rid of. More than 30 percent of the people are likely to develop a dependency with the long time duration. The risk of dependency becomes highest if the person is alcoholic or has a history of substance abuse.
The withdrawal symptoms include anxiety, nausea, depression, insomnia, nightmares, poor memory as well as consolidation. Withdrawal symptoms are most likely to develop if the drug has been continued for more than three weeks. All benzodiazepines are likely to cause respiratory depression in patients with pulmonary disease.
Non-benzodiazepine Hypnotics
The non-benzodiazepines bind to their specific receptors in the central nervous system. Benzodiazepines have minimal impact on the cycle of sleep stages. There is no REM sleep rebound. Tachyphylaxis is uncommon. The dose of non-benzodiazepines should be reduced in older patients especially the ones having kidney or liver conditions. Zopiclone is an example of non-benzodiazepine. Overall, they have fewer side effects. The newer agents cause psychomotor retardation and impaired memory. The approved non-benzodiazepines include zolpidem, sonata, lunesta and ambien.
· Zopiclone 7.5mg and 10mg
Zopiclone is a hypnotic drug and involves the allosteric modulation of a GABA receptor. it acts by enhancing the binding of channel blocker [(35)S]-TBPS.
· Zolpidem
The quality of sleep can be improved by drugs like zolpidem that act by increasing the stage 2 and slow-wave sleep stage. Tolerance is not observed as a side effect of this medication. A dose of more than 20mg is highly not recommended.
· Zaleplon
Sleep onset latency can be decreased by the action of Zaleplon. It can be re-administered in the body of the patient, following the nocturnal awakenings. It is most useful for patients who wake up in the middle the of night and have trouble falling back to sleep. Its effectiveness can last up to four hours. As compared to the benzodiazepines, zaleplon causes less memory and psychomotor impairment. Visual disturbances have been reported in patients using zaleplon. The most common complication is not seeing colors the way people used to before.
· Eszopiclone
It is an isomer of zopiclone and is the only FDA-approved hypnotic that can be used for longer than 35 days. Its effects are known to alleviate over time. it significantly reduces the wake time duration during the night. It also improves the quality of sleep of a patient. For good sleep maintenance, higher doses of 2 to 3 mg are more effective. The effectiveness of the medicine is greatly reduced if it is taken with fatty food.
· Ramelteon
It is a selective melatonin receptor that targets the melatonin Mt in the brain. It acts by prolonging the sleep cycle and puts the patient into a deep sleep. Patient evaluation is inconsistent and no comparison studies have been conducted so far. The medication has also not been studied in patients with depression, shift work, or anxiety. Severe side effects include migraines, dizziness, fatigue, nausea as well as mental disorientation for brief periods.
The reason for so much diversity in the manufacturing of sleeping pills is that they all have a different targeted approach. In some cases, they act by setting a disorder correctly while in others they just regulate the sleep cycles by inhibiting or correcting the number of inhibitors in our brain.
Over the counter sleeping pills
Nearly 25 percent of the patients use over-the-counter sleeping pills to cure insomnia. They are anti-histamines in their mechanism of action. People usually take them several nights a week. Benadryl and Doxylamine are the most common over-the-counter sleeping pills UK. They are not as effective as other drugs for treating insomnia but if you have a milder form, this is the best-prescribed medication on the market. The most common side effect of this drug is causing residual drowsiness.
Herbal Medication
There are many drugs in the market that have are been extract from the plants. This is referred to as “herbal treatment”. There are many dietary supplements like lavender, valerian root, passionflower, glutamine, niacin as well as melatonin. Among these, the most effective as valerian and melatonin. People usually tend to prefer herbal medication as they have lower side effects and they are cheaper to purchase.
However, the benefit of buying sleeping pills in the UK is that they are very specific in their action and will act by targeting your problem. That means you have a permanent solution for the imbalance in your brain.
Wrapping it Up
Zopiclone 7.5mg is is very effective in its mechanism of action and will put your sleeping patterns in the right order in just a matter of seven to ten days. Among the many drugs that treat insomnia, zopiclone is the best choice for the majority of consumers. That is why people prefer buying it.
